Cell Biology of Development

Saint Laboratory

• Rho small GTPase Signalling in Cell division
• Epithelial-Mesenchymal transitions and cell migration in Drosophila
• Genetic modifiers of pbl function
• The autoimmune regulator Roquin induces and localizes to stress granules through its unique Roq domain

Campbell Laboratory

• Mammalian homologues of Drosophila melanogaster genes involved in development and neurobiology

Gene Regulatory Mechanisms

Whitelaw Laboratory

• Mechanism and function of Nxf
• Gene regulation by the Single Minded transcription Factors
• Deciphering the posttranslational code of the Dioxin Receptor
• Novel functions of the Hypoxia Inducible Factor HIF-1a

Peet Laboratory

• Novel targets of FIH-1
• Characterisation of Notch1 asparaginyl hydroxylation by FIH 1
• Physiological role of FIH-1 during development
• Differential regulation of HIF-1a and HIF-2a

Development and Evolution

Ball Laboratory

• Coral Genomics and Development: EST and microarray Studies
• Molecular control of metamophosis in the coral Acropora millepora
• Conserved developmental pathways in evolution

Development and Human Disease

Richards Laboratory

• The function of the WWOX that spans the common chromosomal fragile site
• The normal role of the huntingtin protein

Arkell Laboratory

• How does Zic2 cause Holoprosencephaly?
• What is the molecular mechanism of Zic gene function?

Molecular Developmental Neurobiology

Lardelli Laboratory

• The molecular pathology of Alzheimer's disease using the zebrafish
• Role of presenilin genes in Alzheimer's

Maleszka Laboratory

• Behavioural genomics of the honeybee
• The neurobiology of honeybee altruism
• Genome methylation in epigenesis

Koblar Laboratory

• Neural stem cells from adult rodent brain
• Dental pulp stem cells from human teeth
• Mechanism and function of Nxf
  

Jensen Laboratory

• Post-transcriptional gene regulation in the vertebrate nervous system
• How the metabolism of pre-mRNA and mRNA are controlled in neurons

Cell Programming

Rathjen Laboratory

• Pluripotence in mammalian embryonic stem cells: What makes these cells tick?

• Lineage-specific differentiation of pluripotent ES cells: Understanding the molecular cues that regulate differentiation to the primary germ lineages during mammalian gastrulation.

• Deciphering the body's language: The signalling pathways that lead to positional specification in the neural tube.