MOLECULAR DEVELOPMENTAL NEUROBIOLOGY
Koblar laboratory's major interest is in developmental neurobiology. Our broad
focus is to understand the molecular and cellular mechanisms underlying the
assembly of the nervous system and how lessons learnt from this may give rise
to novel strategies of brain repair in stroke.
Currently, there are two major research projects undertaken in the laboratory.
First, are the molecular and cellular investigations into the basic biology
of adult mammalian stem cells and how this may relate to neural tissue engineering.
adult stem cells populations are studied: (1) Neural stem cells from adult rodent
brain and (2) dental pulp stem cells from human teeth. Second, is the study
of Nxf, a transcription factor of the bHLH-PAS family, and its potential role
in neurogenesis. Our laboratory discovered this novel gene in 2004.
Koblar Lab - June 2006
Collaborators & Linkages
- Dr Stan Gronthos, Dept Haematology, IMVS, Adelaide, SA
- A/Prof Murray Whitelaw, University
of Adelaide, SA
- Dr Stephen Minger, Wolfson Centre for Age Related Diseases, London, UK.
- Prof Pat Doherty, Wolfson Centre for Age Related Diseases, London, UK.
- ARC/NHMRC Research Network in Genes and Environment in Development (NGED)
Publications (since 2000)
Stokowski, A., Shi, S., Sun, T., Bartold, P.M., Koblar, S.A., Gronthos, S.(2007)
EphB/Ephrin-B Interaction Mediates Adult Stem Cell Attachment, Spreading, and
Migration: Implications for Dental Tissue Repair. Stem Cells. 2007 Jan;25 (1):156-64.
Milton, A.G., Jannes, J., Hamilton-Bruce, M.A., Koblar, S.A. (2006) Activating
mutation of the renal epithelial chloride channel CIC-Kb predisposing to hypertension.
Hypertension 47 e12-3.
Armstrong CA, Bevan SN, Gormely KT, Marcus HS, Koblar SA (2006). Tissue plasminogen
activator - 7351C/T polymorphism and lacunar stroke. Stroke 37(2):329.
Jayasena, C.S, Flood, W.D., Koblar, S.A. (2005) High EphA3 expressing ophtalmic
trigeminal sensory axons are sensitive to ephrin-A5-Fc: implications for lobe
specific axon guidance. Neuroscience 135: 97-109
Cai, Z., Blumbergs, P.C., Koblar, S.A., Cash, K., Manavis, J., Ghabriel, M.N.,
Thompson, P.D. (2004) Peripheral nervous system and central nervous system pathology
in rapidly progressive lower motor neuron syndrome with immunoglobulin M anti-GM1
ganglioside antibody. Journal of the Peripheral Nervous System 9: 79-91
Jannes, J., Hamilton-Bruce, M.A., Pilotto, L., Smith, B.J., Mullighan C.G.,
Bardy P.G., Koblar, S.A. (2004) Tissue plasminogen activator - 7351C/T enhancer
polymorphism is a risk factor for lacunar stroke. Stroke 35: 1090-4
Eberhart J., Swartz M.E., Koblar S.A., Pasquale E.B., Krull C.E. (2002). EphA4
constitutes a population-specific guidance cue for motor neurons. Developmental
Biology 247: 89-101
Varelias A, Koblar SA, Cowled PA, Carter CD, Clayer M. (2002). Human osteosarcoma
expresses specific ephrin profiles: implications for tumorigenicity and prognosis.
Coulthard, M.G., Lickliter, J.D., Subanesan, N., Chen, K., Webb, G.C., Lowry,
A.J., Koblar, S.A., Bottema, C.D.K., Boyd, A.W. (2001) Characterization of the
EphA1 receptor tyrosine kinase: expression in epithelial tissues. Growth Factors
Krull, C.E., Koblar, S.A. (2000) Motor axon pathfinding in the peripheral nervous
system. Brain Research Bulletin 53:479-487
Eberhart, J., Swartz, M., Koblar, S.A., Pasquale, E.B., Krull, C.E. (2000) Expression
of EphA4, Ephrin-A2 and Ephrin-A5 during Axon Outgrowth to the Hindlimb Indicates
Potential Roles in Pathfinding. Developmental Neuroscience 22:237-250.
Karam, S.D., Burrows, R.C., Logan, C., Koblar, S.A., Pasquale, E.B., Bothwell,
M. (2000), Ephs and ephrins in the developing chick cerebellum: relationship
to sagittal patterning and granule cell migration. Journal of Neuroscience 20(17):6488-6500.
Koblar, S.A., Krull, C.E., Pasquale, E.B., Peale, F.D., Cerretti, D.P., Bothwell,
M. (2000), Ephrin-B1/EphB2 interactions alone do not pattern spinal motor axon
segmentation in the chick. Journal of Neurobiology 42:437-447. (N.B.: Fig. 3
was selected as cover photograph for this Volume 4, Issue 4, 2000)